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Doctors Once Blamed It on “Getting Older,” But New Research Links Cold Extremities and Low Energy to a Silent Internal Decline — And a Nobel Prize Discovery May Hold the Answer.
By Keith Harrison - April 26th, 2025
When 68-year-old John Miller from Utah bounds up the stairs two at a time, his grandkids struggle to keep up.
It’s hard to believe that just a year ago John felt exhausted by mid-afternoon, plagued by cold feet and hands, and worried his best days were behind him.
“I used to fall asleep in my armchair by 8 PM,” John recalls. “My energy was zero. Even walking up a small hill left me winded. I thought, ‘Well, I’m getting old…’.”
Everything changed when John discovered a remarkable natural breakthrough – a simple daily drink powered by fruit stem cells.
Now, he jokes that he has “the pep of a 40-year-old” at 68. He has resumed his favorite hobbies – hiking, biking, even dancing – with stamina to spare.
His doctor was astonished to see John’s blood pressure readings looking 20 years younger, and John himself can’t stop grinning at the return of that “zest for life” he thought was gone forever.
And John’s not alone.
Meet 72-year-old Marilyn.
She had been struggling with low energy and nagging health concerns – slow circulation left her hands numb on cold days, and her blood pressure crept up year after year.
She felt older than her age and feared it was only downhill from here.
But that was before Marilyn tried this new grape-and-apple skin stem cell formula.
Now, at 72, she says “I have days where I feel 45!”
Marilyn has the energy to garden for hours, takes brisk walks every morning on the beach, and even notices sharper memory and focus.
Friends tell her she “glows” with vitality – and her latest checkup showed her blood pressure is back in the healthy range.
So, what did John and Marilyn do differently?
How did they go from feeling drained and “old” to vibrant, energetic, and youthful?
Surprisingly, all it took was restoring one thing inside their bodies – something scientists call the “spark of life” molecule.
If you're experiencing any of these symptoms, your body may be oxygen-starved due to poor circulation from unhealthy layers of cells called the endothelium:
Cold hands and feet (even when the rest of your body feels warm)
Constant fatigue that no amount of rest can fix
Brain fog that makes you feel like you're thinking through mud
Stubborn high blood pressure that won't respond to medications
Numbness or tingling in hands and feet
Declining memory and mental sharpness
Feeling dizzy when standing up
Cuts and bruises that heal slowly
If you’re over 50, you might have noticed a dip in your energy or health that you just can’t explain.
Fatigue, memory lapses, cold extremities, rising blood pressure or cholesterol, fading stamina, maybe even a flagging libido – we often blame these on age.
But emerging science shows these frustrating symptoms are often just that: symptoms of an underlying issue.
In fact, researchers have discovered a common thread behind many ailments of aging, from fatigue to heart concerns.
It all comes down to your body’s ability to produce a tiny molecule called nitric oxide.
You may have never heard of nitric oxide (NO), but it’s absolutely vital to feeling young and healthy.
In fact, nitric oxide’s importance is so great that three scientists won the Nobel Prize in Medicine in 1998 for discovering its role in the human body.
Nitric oxide (NO) is often nicknamed the “spark of life” because it literally fires up your circulation.
What does it do?
Think of NO as a messenger that tells your blood vessels to relax and open up.
When NO is released, your arteries expand like a hose opening wider, allowing oxygen-rich, nutrient-rich blood to surge through your body.
This blood delivers life-giving oxygen and nutrients to every organ and tissue – from your heart and brain down to your hands, feet, and even skin.
In youth, our bodies produce plenty of nitric oxide to keep that blood flow humming.
That’s why kids and young adults seem to have boundless energy and recover quickly.
Scientific research shows nitric oxide production drops dramatically after age 40, with an 85% decline by age 70.
But after about age 40, this “spark of life” starts to dim. By your 50s and 60s, nitric oxide levels plunge dramatically.
How dramatically?
Studies show that by the time we reach our 70s, we’ve lost as much as 75-85% of our nitric oxide production!
It’s as if the body’s natural “oil” is running dry, and the engine starts to sputter.
When your NO levels drop, you feel it. Your circulation isn’t as strong as it used to be, so cells around your body start getting less oxygen and nutrients.
The result? You begin noticing those classic “getting older” issues:
Low energy and endurance: without ample oxygen, your muscles tire faster. You may feel wiped out by midday or need naps.
Brain fog and memory slips: reduced blood flow to the brain can make it harder to concentrate or recall names.
Cold hands and feet, numbness: poor circulation leaves your extremities chilly and sometimes tingly or numb (sound familiar?).
Aches and pains: joints and tissues don’t get the nutrients to repair as quickly, leading to stiffness or discomfort.
Rising blood pressure and heart strain: constricted blood vessels force your heart to work harder, often sending blood pressure up.
Trouble sleeping: some folks even find poor circulation affects their sleep quality, leading to tossing and turning.
Declining stamina and libido: let’s be honest, when your “pump” isn’t pumping like it used to, everything from exercise to intimacy can suffer.
Do some of those issues ring a bell?
Many of us over 50 experience several of these. We often shrug and say “I’m just getting old.”
But in truth, these are signals that your body is low in nitric oxide and thus your blood flow is impaired.
The good news is, by re-igniting your body’s nitric oxide levels, you can often reverse these symptoms, renewing your energy, vitality, and health from the inside out.
John and Marilyn’s stories above are perfect examples – when they boosted their nitric oxide, they saw amazing changes.
“It’s like someone flipped the lights back on in my body,” Marilyn laughs. “Now I wake up refreshed, my hands stay warm, and even my hair and skin look better.”
Perhaps you’ve heard of taking L-arginine or beetroot for better circulation. It’s true that certain nutrients can help increase nitric oxide.
But if you’ve tried one of those supplements and been disappointed (or overwhelmed by taking handfuls of pills), there’s a reason why.
Most nitric oxide supplements on the market are based on 30-year-old science. They rely on the amino acid L-arginine.
Back in the 1990s, L-arginine was the first known building block for nitric oxide, and many products sprang up claiming to boost NO.
But modern research and real-world trials have revealed a problem: L-arginine supplements barely move the needle for people over 40.
Here’s the kicker – to get a benefit, you must take huge doses of L-arginine (often 6,000–7,000 mg a day or more). Even then, studies show it might increase blood flow by a meager 1.8–10% on average.
That’s not even noticeable!
And to add insult to injury, long-term high-dose L-arginine use can cause nasty side effects: bloating, digestive distress, blood pressure swings, and even damage the very blood vessel cells you’re trying to help (scientists call this the “arginine paradox”).
Plus, L-arginine powders taste incredibly bitter – not exactly something you look forward to daily.
Then what about beetroot? Beetroot is a natural source of dietary nitrates, which help relax and widen blood vessels — thereby improving circulation.
Clinical studies show beetroot can improve circulation by an average of 10-20%, depending on the dose, form, and individual response.(14)
The challenge?
You’d have to drink beet juice or eat large quantities of nitrate-rich vegetables like spinach every single day to maintain those benefits — and results can vary widely. (One study found that a beet grown in certain soil could contain 50 times more nitrates than a beet from another region!)
So diet alone becomes a guessing game, and most of us just won’t consume that quantity daily (or deal with bright red beet-juice stains constantly!).
Finally, there’s a hidden obstacle: as we age, our bodies become less efficient at utilizing these nitric oxide sources.
Believe it or not, using antiseptic mouthwash or certain toothpastes can kill off friendly bacteria in your mouth that help turn dietary nitrates into nitric oxide (Don’t worry – you don’t have to give up mouthwash to solve this, as you’ll see).
The bottom line is that older adults need a more effective solution to restore nitric oxide – one that doesn’t require huge pill doses, random vats of beet juice, or drastic lifestyle changes.
That’s where the exciting new discovery that helped John and Marilyn comes in.
Scientists have identified a “missing link” in natural nitric oxide production – a breakthrough nutrient that is up to 10 times more effective than arginine or beet alone in boosting blood flow.
It’s derived from the stem cells of certain fruits and is so potent that one small daily dose can dial your circulation back decades.
Not long ago, a team of European researchers were investigating why diets rich in fruits (especially grapes and apples) were linked to heart health and longevity.
Red wine and apples are staples of the heart-healthy Mediterranean diet, and scientists suspected certain natural compounds in these fruits greatly enhance blood vessel function.
Their hunch proved correct – but the real challenge was extracting those youthful compounds in a potent form.
It took years of study to crack the code.
Finally, using cutting-edge extraction technology, scientists isolated a blend of polyphenols from rare apple and grape stem cells – the parts of the fruit with the highest concentrations of these “miracle molecules.”
They named this discovery ViNitrox™, and it would change everything we know about natural circulation support.
So, what exactly is ViNitrox?
It’s a proprietary blend of polyphenols (think powerful antioxidants) derived from grape and apple skin stem cells – essentially the nutrient-dense essence of the fruit.
These polyphenols include a special class of compounds that trigger a surge in nitric oxide production.
In lab tests, ViNitrox showed jaw-dropping effects.
In fact, an animal study compared ViNitrox head-to-head against a pharmaceutical vasodilator (a lab chemical specifically designed to open arteries).
The result: ViNitrox opened blood vessels by 50% – nearly matching the drug!
To put that in perspective, recall that most over-the-counter NO boosters (like L-arginine) might achieve 1–10% dilation at best.
ViNitrox’s 50% improvement makes it arguably the most powerful natural nitric oxide booster on the planet.
It means dramatically more blood flow, delivering more oxygen and nutrients wherever your body needs it.
No wonder people like John report feeling “young and invigorated” again – their cells are finally getting fed and oxygenated like they did in youth.
And it’s not just about blood flow.
Another clinical study (this time in humans) found that ViNitrox’s apple-and-grape polyphenols also slashed inflammation by 50% over just 28 days.
That’s big news, because chronic inflammation is a known driver of aging and many health issues.
By reducing inflammation, these fruit nutrients help create an internal environment where your heart, arteries, joints and immune system can thrive.
Graph from a clinical study showing a 50% increase in blood flow.
Clinical studies showed:
ViNitrox™ dilated blood vessels by 50% – more than 10 TIMES better than L-arginine's typical 1.8%-10% improvement
ViNitrox™ reduced inflammation by 50% in just 28 days
ViNitrox™ showed significant protective effects against free radicals (which are created when nitric oxide is produced)
ViNitrox™ demonstrated consistent effectiveness without diminishing returns over time
In short, ViNitrox not only boosts your “life energy” circulation, it also protects your body while it does so.
Scientists had never seen such a one-two punch from a natural compound before: significantly increase nitric oxide AND reduce inflammation.
It’s like turning back your body’s clock on two fundamental levels.
Naturally, the question became: How can we make this miracle nutrient available to everyone, especially people in their 50s, 60s, 70s and beyond who need it most?
The answer came in the form of an easy, daily drink mix called OxyBoost™ (the same breakthrough John and Marilyn used).
OxyBoost is a new “enhanced nitric oxide booster” drink that uses ViNitrox™ as its star ingredient, along with a supporting cast of other science-backed nutrients to restore youthful circulation.
It comes in a tasty natural grape flavor, so it’s enjoyable and easy to take every day.
Unlike many supplements that come as pills (hard for some to swallow) or sickly sweet concoctions, OxyBoost is a simple drink mix.
You just stir one scoop into water (or your favorite beverage) and let nature’s circulatory secret go to work.
As you drink it, you’re literally feeding your bloodstream the exact nutrients it needs to produce nitric oxide and rejuvenate those tired blood vessels.
One thing readers really want to know: How quickly can I expect to feel a difference?
The answer, if OxyBoost's ingredients and user reports are any indication, is very quickly.
Remember John’s story at the beginning? He said that now he doesn’t even need his evening coffee – after taking OxyBoost, his “energy just stays up” and he feels alert and alive through the day.
Many users experience what can only be described as an “awakening” of their body’s vitality.
For some, the changes might be subtle at first – maybe you notice you aren’t as cold anymore, or you don’t get that afternoon slump of fatigue.
For others, it’s more dramatic – a burst of energy, a feeling of “wow, I haven’t felt this good in years!”.
One gentleman in his late 50s shared that after starting OxyBoost, he went from struggling to jog a mile to comfortably running three miles non-stop, in just a few weeks.
Another user, a 62-year-old grandmother, reported: “My hands stopped tingling and even my vision seems clearer. I’m gardening and dancing again!”
(These are actual experiences, and individual results can vary, of course.)
The clinical studies I shared earlier back up these anecdotes.
These kinds of results show that improving your circulation impacts nearly every aspect of health – from metabolic measures to mood and sleep quality.
It makes sense: when your cells are finally getting fed and oxygenated properly, everything works better.
You wake up refreshed, your mind is sharper, and even your sex drive might return (after all, healthy blood flow is key there, too!).
Imagine your life with this kind of youthful vitality flowing through your veins. What would you do that you don’t do now?
Play a sport you thought you had to give up? Travel and actually enjoy those walking tours? Dance at your granddaughter’s wedding instead of watching from the sidelines?
The possibilities open up when you have the energy and health to embrace them.
Thousands of people over 55 are already enjoying these kinds of benefits thanks to OxyBoost and its nitric oxide-boosting power. Why not you, too?
ViNitrox™, the special compound they extract from apple and grape skin stem cells, provide four critical benefits:
Boosts Circulation and Blood Flow: They make your blood vessels expand up to a 50% wider compared to only 1.8% - 10% from arginine and other nitric oxide boosters.
Potent Anti-Inflammatory Action: Clinical studies show ViNitrox™ reduces inflammation by up to 50% in just 28 days.
Free Radical Protection: When your body makes nitric oxide, it also makes harmful particles called free radicals. The special fruit stem cell extracts in OxyBoost™ help destroy these bad particles.
Endothelial Cell Support: It helps repair the endothelial cells where nitric oxide is produced, addressing the root cause of your nitric oxide levels dropped in the first place.
Comparison
OxyBoost™ with ViNitrox™
L-Arginine Based Products
Increase in Circulation
Up to 50%
1.8% - 5%
Anti-Inflammatory Effects
Reduces inflammation by 50%
No significant anti-inflammatory effects
Antioxidant Protection
Yes - neutralizes free radicals from N.O.
No - may increase oxidative stress
Tolerance Development
No diminishing returns
Requires increasingly higher doses
Clinical Dosage
500mg (exact amount used in studies)
Often underdosed (7,000mg needed)
Want to know something impressive about OxyBoost™? You can see it working with your own eyes! Just get some nitric oxide test strips from any drugstore.
Many people who take OxyBoost™ do this test.
On day one, their test strip turns light pink, showing "Low" nitric oxide. But after just a few days of taking OxyBoost™, their test strip turns dark pink, showing "Optimal" nitric oxide.
It's like watching your body get healthier right before your eyes!
But the best part is how people feel:
Their hands and feet get warmer
They have more energy all day long
They can think more clearly
They just feel better overall
To match the circulation benefits of just ONE bottle of OxyBoost™, you would need to purchase 14 bottles of typical L-arginine nitric oxide boosters at $35 each – a total of $490!
Plus, OxyBoost™ provides additional anti-inflammatory and antioxidant benefits that L-arginine products don't offer at any price.
As you get older, the tiny factories (endothelial cells) in your body that make nitric oxide become damaged. By age 70, they make 85% less nitric oxide than when you were young.
These factories need to be fixed before they can work right again.
That's why we call the first month the "Repair Phase." During this time, you need to take two OxyBoost™ capsules twice a day.
This helps fix those tiny factories in your body.
It takes about 30 days to repair the damage. After that first month, you only need to take one scoop a day (one bottle per month) to keep your nitric oxide levels high.
We're so confident OxyBoost will transform your health, we offer an unprecedented triple guarantee:
You MUST feel noticeably more energetic within 7 days
You MUST experience warmer hands and feet within 21 days
You MUST feel dramatically healthier within 90 days
If you don't experience ALL THREE improvements, simply give us a call at 833-699-7727 or send us an email at support@oxynaturals.com for a 100% refund. No questions. No hassles.
As Dr. Mitchell tells his patients: "I can't promise OxyBoost™ will work for everyone, but when you have Nobel Prize-winning science, clinical studies showing a 50% improvement in blood flow, and a 90-day money-back guarantee, it certainly deserves a try."
Up to 50% increase in blood flow
Up to 50% reduction in inflammation
Significant improvements in energy levels
Support for healthy blood pressure
Enhanced cognitive function
Improved exercise and sexual performance
Remember: Cold hands and feet are your body's early warning sign. Don't ignore this crucial signal. Take action now while you can still address the underlying cause.
Right now, you're at a crossroads. You can:
Continue with supplements that only work at 5% capacity
Do nothing and watch your nitric oxide levels continue to decline
Try OxyBoost completely risk-free and potentially transform your health
Remember, with our 90-day guarantee, you have nothing to lose and everything to gain.
The future of anti-aging is here.
This breakthrough is too important to ignore. Don't let declining nitric oxide levels rob you of your vitality. Take advantage of this special offer now and start feeling younger, more energetic, and healthier - or pay nothing.
WARNING: Due to recent media exposure and overwhelming demand, supplies of OxyBoost are limited. Order now to secure your supply and get up to 45% off today.
Effect of ViNitrox® on the activation of eNOs through the phosphorylation of “Serine 1177” from endothelial cells (HUVECs) as measured by flow cytometry (2010)
Ex-Vivo laboratory study: ViNitrox® stimulates the production of nitric oxide (NO) by vascular endothelium
Inflammation in atherosclerosis: Imaging, biomarkers and novel therapeutic opportunities
Acute L-Arginine supplementation does not increase nitric oxide production in healthy subjects
Tangadi, D., Bhutani, N., & Bhavsar, P. (2020). Coronary Artery Disease, Nitric Oxide, Insulin Resistance, Polymorphism, RFLP.
Wang, Y., Cheng, K., Lam, K., Wu, D., Wang, Y., Huang, Y., Vanhoutte, P., Sweeney, G., Li, Y., & Xu, A. (2011). APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice. Diabetes, 60, 3044–3054.
House, L. M., Morris, R. T., Barnes, T. M., Lantier, L., Cyphert, T. J., McGuinness, O., & Otero, Y. (2015). Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance. Cardiovascular Diabetology
Sprague AH, Khalil RA. "Inflammatory cytokines in vascular dysfunction." Biochem Pharmacol. 2009
Steyers CM, Miller FJ. "Endothelial dysfunction in chronic inflammatory diseases." Int J Mol Sci. 2014
Gimbrone MA, García-Cardeña G. "Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis." Circ Res. 2016
ADVERTORIAL NOTICE: This is a paid advertisement for OxyBoost, not an objective news article, review, or consumer report. This advertisement is a dramatization based on customer testimonials and shared experiences. Individual results vary and are not guaranteed. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.