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Clinically Proven Formula
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29,000+ Happy Customers
Clinically Proven Formula
90-Day Money-Back Guarantee
Free Shipping on Multi-Bottle Orders
29,000+ Happy Customers
Clinically Proven Formula
90-Day Money-Back Guarantee
Free Shipping on Multi-Bottle Orders
29,000+ Happy Customers
Clinically Proven Formula
90-Day Money-Back Guarantee
Free Shipping on Multi-Bottle Orders
29,000+ Happy Customers
Clinically Proven Formula
90-Day Money-Back Guarantee
I had heard about nitric oxide benefits and was taping my mouth shut at night, so the body, it is said, would make more of the nitric oxide by nose breathing! It was an ok experience.
Seeing the oxyspark ad intrigued me. I purchased the product and began using it! I am 72 year old women, and I immediately felt the energy increase, and I can’t do without this amazing product!! Love love love it!!! Thankyou!!
Tanya Blanton
Customer Reviews
I thought it might be valuable to future prospective customers to know what I think about your tremendous products. I am a retired 80-year-old Doctor of Science (D.Sc.) biochemist and former national trainer for years for other nutrition products firms since the 1970's when I also was the youngest scientist speaker for the National Health Federation conventions and other organizations, and a university administrator. I am a consumer of only the finest nutritional products.
As soon as I evaluated your OxySpark formula I ordered a case of it the next day and recommend it to all my clients. No other formula in this industry has such a comprehensive formula that is remarkably effective for the generation of whole-body sustained energy generation at cellular level for increased stamina and endurance with no negative side effects or without the typical crash found in other supplements. It provides an extra energy spark to my life that is soft and smooth without being hyper.
Personally, for me I outwork and exercise people 1/3 my age every day and I also speed walk 7 miles 5 days a week. This firm's total product line is so remarkable and well researched that I would recommend them to anyone else just as I do to my own high-performance clients. Everyone comments on my brilliant memory and high energy performance as I still work full time for the joy of helping others in their senior years and being a mentor to young people as well. My own physician says I have the best chance of all their patients over the years to live to age 100 and that I didn't need to see them for any health issue.
I now prescribe OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and | have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening.
I started using OxiSpark seven yrs ago, im 2018 when I switched from L -Arginine as I saw little improvement. Ar the tine. I was the young age of 78. and I am now 85. Today, I greatly attribute the reason for my present and improved well being to OxidSpark (in addition to a healthy life style which imcldes a moderate amount of physical activity and Physical Therapy, when needed.) I started with nutritional supplementation over 50 yrs ago, at the age of 32, and it helped me greatly as I grew older. Because I genetically predisposed to have varicose veins, I also always were support stockings. Later in life, I developed other conditions including Venous Insufficuency and peripheral neuropathy (both of them aggravated by insufficient oxygen in blood circulation) In 2017, I was diagnosed eith a condition called Lipodermatosclerosis (AKA Stasis dermatitis) which looks like Lymphodema due to the swelling, but it is not the same and has a different cause). There is no recognized cure for this and it has a prognosis of becoming progressively worse.
As a result of getting this, my legs would swell up so much that I would get ulcers in my feet, and sometimes a cellulitis infection in my legs. This would happen even though I always continued to ware support stocking. This condition is not unusual for diabetics, but I do not fit in that category and my A1C is always good. But when I am dealing with an infection, such as Covid, due to inactivity, my legs would swell. So in order to avoid this, I just increase the number of times a day I take OxiSpark, and as a result it assists with my recovery.
After continuous daily use, the dark brown discoloration on my legs has disappeared and not meaning to brag, my legs look great. The many age spots on my hands and arms have gotten considerably lighter and most of them have disappeared. Not only that, the general appearance of my hands have taken on the appearance of a much younger person (without having had a special procedure to mitigate the veiny appearance comman with older women). Because it increases oxygenation, OxySpark is good for brain and heart health. Take the time and read the literature. It is true, and I am living testimony!
The only supplement that has stood the test of time.
I have used this for years and continue to feel the positive this supplement provides.
Thank You
I start every day with OxySpark for over the last four years. I am 88 years old and in very good health. No meds from my doctor.
OxySpark
OxySpark’s delicious fruit stem cell drink is proven to optimize blood flow, fill every cell with revitalizing oxygen, and naturally increase energy without L-Arginine or synthetic stimulants.
Increase your energy levels naturally without stimulants.
Enjoy a sharper focus and memory throughout the day
Recommended by cardiologists for optimal cardiovascular health.
Supports healthy blood pressure
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Product Overview
Harness the power of nature with OxySpark, our most advanced circulation and nitric-oxide–boosting drink powder. This delightful fruit-stem-cell blend ignites blood flow, sharpens mental clarity, and fuels full-body energy, without L-Arginine, stimulants, or synthetic additives. Backed by a Nobel Prize, inspired by science, and trusted by over 29,000 satisfied customers.
Specs & Ingredients
ViNitrox™ (apple & grape stem cell polyphenols): Clinically proven to boost nitric oxide by ~24%, enhance blood flow up to 50%, reduce inflammation, and neutralize free radicals. Same dosage used in human clinical trials.
L-Citrulline: Converts into L-Arginine in the body to sustain nitric oxide production naturally, promoting vasodilation, endurance, and enhanced oxygen delivery.
Organic Beet Root Powder: A natural source of nitrates that further support nitric oxide synthesis and stamina, offering a “second-wind” boost.
AstraGin®: A patented extract (astragalus + ginseng) that improves the absorption of L-Citrulline by ~45%, maximizing effectiveness.
CoQ10 & Enzogenol® (pine bark extract): Heart-protective antioxidants that support vascular function, reduce inflammation, and enhance overall cardiovascular support.
How to use them
Just mix one scoop with 8 oz. of water or milk, and you’ll soon start feeling the refreshing, energizing, and circulation-boosting effects of a nitric oxide formula that’s as clean as it is effective.
Timing: Best taken in the morning for all-day circulation, energy, and mental clarity.
Onset of Benefits:
2–3 weeks: Noticeable improvements in energy, warmth in extremities, and cognitive sharpness.
1–3 months: Full benefits—including sustained vitality, improved stamina, clearer focus, and cardiovascular resilience.
Ingredient Facts
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I had heard about nitric oxide benefits and was taping my mouth shut at night, so the body, it is said, would make more of the nitric oxide by nose breathing! It was an ok experience.
Seeing the oxy spark ad, intrigued me. I purchased the product and began using it! I am 72 year old women, and I immediately felt the energy increase, and I can’t do without this amazing product!! Love love love it!!! Thankyou!!
Tanya Blanton
Replaces 6 Supplements,
Saving you Money.
Estimated Traditional Supplement Costs
500mg of Clinical-Dose ViNitrox™
L-Citrulline
AstraGin®
CoQ10
Enzogenol®
Beet Root
$89
$42
$38
$35
$45
$28
Total Monthly Cost if Bought Separately:
$277
OxySpark Nitric Oxide Booster:
$71.21
Real Results from People Just Like You
Discover how Oxyspark has helped others achieve their specific health goals, from the gym to the doctor's office.
Jane K.
Noticeable warmth in my feet
I struggled with cold hands and feet, especially in winter. After three weeks on Oxyspark, the difference is night and day. My circulation feels robust, and I have less of that pins-and-needles feeling. This is a game-changer!
Robert M.
Less stiffness, improved flow
I purchased this to support my overall vascular health. I've noticed less morning stiffness and a clear improvement in blood flow, which helps with my long-term mobility goals. Highly recommend it for aging joints.
Carlos V.
Clearer veins after training
I use Oxyspark daily, and the vascular definition is excellent, even post-workout. It supports efficient blood vessel relaxation and better oxygen delivery. It’s effective, clean, and a non-negotiable part of my routine.
Maria D.
Visible difference in skin health
I didn't expect this, but my skin looks less dull and more vibrant, a definite sign of better circulation! The subtle, full-body vitality it provides is exactly what I was looking for in a supplement.
Why Thousands of People Are Switching To OxySpark
If you struggle with fatigue, brain fog, cold hands and feet, or high blood pressure…OxySpark could be exactly what your body’s been missing.
Most circulation and nitric oxide supplements rely on L-Arginine, a synthetic amino acid that only boosts blood flow for a few hours, but it can cause dangerous side effects, including heart issues and digestive problems.
That’s why more and more people over 50 — along with athletes and health-conscious adults — are ditching arginine-based supplements and turning to OxySpark instead.
Backed by Nobel Prize-winning research, OxySpark uses ViNitrox™️, a natural blend of apple and grape polyphenols that are clinically proven to:
Boost circulation 50%
Safely increase nitric oxide production by 24%
Increase energy levels to combat fatigue
Enhance exercise performance and recovery
Reduce inflammation by 50%
It's time to stop filling your body with harmful supplements that contain L-Arginine.
OxySpark delivers 10x the effectiveness of typical arginine supplements with 100% natural, science-backed ingredients.
Customer Reviews
I thought it might be valuable to future prospective customers to know what I think about your tremendous products. I am a retired 80-year-old Doctor of Science (D.Sc.) biochemist and former national trainer for years for other nutrition products firms since the 1970's when I also was the youngest scientist speaker for the National Health Federation conventions and other organizations, and a university administrator. I am a consumer of only the finest nutritional products.
As soon as I evaluated your OxySpark formula I ordered a case of it the next day and recommend it to all my clients. No other formula in this industry has such a comprehensive formula that is remarkably effective for the generation of whole-body sustained energy generation at cellular level for increased stamina and endurance with no negative side effects or without the typical crash found in other supplements. It provides an extra energy spark to my life that is soft and smooth without being hyper.
Personally, for me I outwork and exercise people 1/3 my age every day and I also speed walk 7 miles 5 days a week. This firm's total product line is so remarkable and well researched that I would recommend them to anyone else just as I do to my own high-performance clients. Everyone comments on my brilliant memory and high energy performance as I still work full time for the joy of helping others in their senior years and being a mentor to young people as well. My own physician says I have the best chance of all their patients over the years to live to age 100 and that I didn't need to see them for any health issue.
I now prescribe OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and | have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening.
I started using OxiSpark seven yrs ago, im 2018 when I switched from L -Arginine as I saw little improvement. Ar the tine. I was the young age of 78. and I am now 85. Today, I greatly attribute the reason for my present and improved well being to OxidSpark (in addition to a healthy life style which imcldes a moderate amount of physical activity and Physical Therapy, when needed.) I started with nutritional supplementation over 50 yrs ago, at the age of 32, and it helped me greatly as I grew older. Because I genetically predisposed to have varicose veins, I also always were support stockings. Later in life, I developed other conditions including Venous Insufficuency and peripheral neuropathy (both of them aggravated by insufficient oxygen in blood circulation) In 2017, I was diagnosed eith a condition called Lipodermatosclerosis (AKA Stasis dermatitis) which looks like Lymphodema due to the swelling, but it is not the same and has a different cause). There is no recognized cure for this and it has a prognosis of becoming progressively worse.
As a result of getting this, my legs would swell up so much that I would get ulcers in my feet, and sometimes a cellulitis infection in my legs. This would happen even though I always continued to ware support stocking. This condition is not unusual for diabetics, but I do not fit in that category and my A1C is always good. But when I am dealing with an infection, such as Covid, due to inactivity, my legs would swell. So in order to avoid this, I just increase the number of times a day I take OxiSpark, and as a result it assists with my recovery.
After continuous daily use, the dark brown discoloration on my legs has disappeared and not meaning to brag, my legs look great. The many age spots on my hands and arms have gotten considerably lighter and most of them have disappeared. Not only that, the general appearance of my hands have taken on the appearance of a much younger person (without having had a special procedure to mitigate the veiny appearance comman with older women). Because it increases oxygenation, OxySpark is good for brain and heart health. Take the time and read the literature. It is true, and I am living testimony!
The only supplement that has stood the test of time.
I have used this for years and continue to feel the positive this supplement provides.
Thank You
I start every day with OxySpark for over the last four years. I am 88 years old and in very good health. No meds from my doctor.
🧠 Improved Focus & Mental Clarity
🔥 Natural Anti-Inflammatory Support
🩸 Better Blood Circulation Without Stimulants
🧠 Improved Focus & Mental Clarity
🧠 Improved Focus & Mental Clarity
🔥 Natural Anti-Inflammatory Support
🩸 Better Blood Circulation Without Stimulants
🧠 Improved Focus & Mental Clarity
What Happens After You Start Taking OxySpark
Experience noticeable improvements in your energy, mental clarity, and blood flow, all without L-Arginine or risky stimulants.
Day 10
ViNitrox™ and fruit stem cell polyphenols begin restoring your body’s nitric oxide production, setting the stage for better blood flow and cellular health.
Day 30
Blood Starts Flowing Freely
You’re likely to begin noticing reduced brain fog, more energy, warmer hands and feet, and less mid-day fatigue as your cells receive more oxygen and nutrients.
Day 90
Revitalize from the Inside Out
Daily use helps you maintain healthy blood pressure, energy, and mental sharpness by naturally supporting your cardiovascular system.
Exactly What OxySpark Gives You
Backed by Nobel Prize-winning science, proven by real people.
Sharpen your Memory & Mental Clarity
Nitric oxide boosts blood flow to the brain, helping you stay focused, think clearly, and reduce brain fog without risky stimulants or synthetic ingredients.
Support Better Circulation
Nitric oxide boosts blood flow to the brain, helping you stay focused, think clearly, and reduce brain fog without risky stimulants or synthetic ingredients.
Increase Your Energy Naturally
Nitric oxide boosts blood flow to the brain, helping you stay focused, think clearly, and reduce brain fog without risky stimulants or synthetic ingredients.
Reignite closeness With Your Partner
Research shows that improving nitric oxide levels supports healthy performance in bed, helping you feel confident and connected again naturally and safely.
Customer Reviews
I thought it might be valuable to future prospective customers to know what I think about your tremendous products. I am a retired 80-year-old Doctor of Science (D.Sc.) biochemist and former national trainer for years for other nutrition products firms since the 1970's when I also was the youngest scientist speaker for the National Health Federation conventions and other organizations, and a university administrator. I am a consumer of only the finest nutritional products.
As soon as I evaluated your OxySpark formula I ordered a case of it the next day and recommend it to all my clients. No other formula in this industry has such a comprehensive formula that is remarkably effective for the generation of whole-body sustained energy generation at cellular level for increased stamina and endurance with no negative side effects or without the typical crash found in other supplements. It provides an extra energy spark to my life that is soft and smooth without being hyper.
Personally, for me I outwork and exercise people 1/3 my age every day and I also speed walk 7 miles 5 days a week. This firm's total product line is so remarkable and well researched that I would recommend them to anyone else just as I do to my own high-performance clients. Everyone comments on my brilliant memory and high energy performance as I still work full time for the joy of helping others in their senior years and being a mentor to young people as well. My own physician says I have the best chance of all their patients over the years to live to age 100 and that I didn't need to see them for any health issue.
I now prescribe OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and | have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening.
I started using OxiSpark seven yrs ago, im 2018 when I switched from L -Arginine as I saw little improvement. Ar the tine. I was the young age of 78. and I am now 85. Today, I greatly attribute the reason for my present and improved well being to OxidSpark (in addition to a healthy life style which imcldes a moderate amount of physical activity and Physical Therapy, when needed.) I started with nutritional supplementation over 50 yrs ago, at the age of 32, and it helped me greatly as I grew older. Because I genetically predisposed to have varicose veins, I also always were support stockings. Later in life, I developed other conditions including Venous Insufficuency and peripheral neuropathy (both of them aggravated by insufficient oxygen in blood circulation) In 2017, I was diagnosed eith a condition called Lipodermatosclerosis (AKA Stasis dermatitis) which looks like Lymphodema due to the swelling, but it is not the same and has a different cause). There is no recognized cure for this and it has a prognosis of becoming progressively worse.
As a result of getting this, my legs would swell up so much that I would get ulcers in my feet, and sometimes a cellulitis infection in my legs. This would happen even though I always continued to ware support stocking. This condition is not unusual for diabetics, but I do not fit in that category and my A1C is always good. But when I am dealing with an infection, such as Covid, due to inactivity, my legs would swell. So in order to avoid this, I just increase the number of times a day I take OxiSpark, and as a result it assists with my recovery.
After continuous daily use, the dark brown discoloration on my legs has disappeared and not meaning to brag, my legs look great. The many age spots on my hands and arms have gotten considerably lighter and most of them have disappeared. Not only that, the general appearance of my hands have taken on the appearance of a much younger person (without having had a special procedure to mitigate the veiny appearance comman with older women). Because it increases oxygenation, OxySpark is good for brain and heart health. Take the time and read the literature. It is true, and I am living testimony!
The only supplement that has stood the test of time.
I have used this for years and continue to feel the positive this supplement provides.
Thank You
I start every day with OxySpark for over the last four years. I am 88 years old and in very good health. No meds from my doctor.
What’s Inside OxySpark™
Our most advanced, powerful blend of clinically studied ingredients is designed to help you improve circulation, boost nitric oxide, and support full-body energy without stimulants.
ViNitrox™
A patented blend of grape and apple polyphenols shown to:
Boost nitric oxide by 24%
Improve blood flow by 50%
Reduce inflammation by 50%
Neutralize free radicals that damage cells during nitric oxide production
It's the same ingredient and dosage used in clinical trials to restore vascular function and support energy, heart health, and mental clarity naturally.
L-Citrulline
A naturally occurring amino acid that works with ViNitrox™ to safely increase nitric oxide levels without the harsh side effects of L-Arginine pills.
Helps your body naturally raise its own L-Arginine levels
Promotes stronger vasodilation and blood flow
Enhances oxygen delivery to muscles and the brain
Beet Root Powder
Provides an additional nitrate pathway to further boost nitric oxide levels.
Reinforces ViNitrox™ effects on blood vessel health
Supports endurance and recovery
Popular among athletes for circulation and stamina
AstraGin®
A patented extract from astragalus and Panax notoginseng that enhances nutrient absorption.
Increases L-Citrulline absorption by 45%
Helps the body absorb key amino acids faster
Maximizes nitric oxide production efficiency
CoQ10
A heart-healthy antioxidant that fuels energy production at the cellular level.
Decreases cell oxidative stress and improves mitochondrial function
Promotes peak cardiac performance
Reduces free radical damage linked to fatigue
Enzogenol®
A natural extract from New Zealand pine bark with powerful anti-inflammatory effects.
Reduces LDL cholesterol levels & systolic blood pressure
Supports healthy blood circulation
Reduces the risk of age-related eyesight deterioration
WARNING: If Your Blood Flow Supplement Contains L-Arginine, You MUST Stop Taking It Now!
Most blood flow supplements rely on high doses of L-Arginine. Studies show L-Arginine only improves blood flow by an average of 1.8% to 10% and the effect fades within hours.7
L-Arginine is an amino acid often used in generic nitric oxide supplements to temporarily dilate blood vessels. But the results are usually short-lived and often come with huge side effects, especially in older adults. Some negative side effects of l-arginine:
Can cause bloating, diarrhea, and stomach cramps
Linked to reactivation of viruses like herpes in sensitive users
Often requires high doses (7,000mg+) for minimal effect
May stress the kidneys and liver with long-term use
Not well tolerated in people over 40 due to declining enzyme activity
Worse, recent studies show L-Arginine’s effectiveness plummets as you age, making it a risky and unreliable long-term solution.17
OxySpark works without L-Arginine. It contains clinically studied, natural ingredients that are proven to boost nitric oxide by 24%, improve heart health, and increase circulation by 50%.
It’s a smarter, plant-based formula thousands of people your age are already using to improve energy, heart, and brain health.
Natural Way To Improve Your Focus, Increase Energy & Support Heart Health Without L-Arginine
Unlike most nitric oxide boosters that rely on high doses of L-Arginine, OxySpark uses a clinically studied, low-dose ViNitrox™ formula that works better and faster, naturally.
Boosts Circulation & Heart Health
OxySpark helps your body produce more nitric oxide, a critical molecule that relaxes and widens blood vessels.
Better circulation means better performance, endurance, and cardiovascular support.
Promotes vascular flexibility for easier blood flow and less resistance.
Supports endothelial function, the inner lining of blood vessels that regulates pressure.
Aids nutrient delivery to vital organs like your brain, heart, and muscles.
Energizes Without Stimulants
Unlike caffeine-based energy products that spike and crash, OxySpark provides clean, sustained energy.
By naturally improving circulation and oxygenation, your body feels more alert, vital, and energized all day long without the jitters or crashes.
Increases cellular oxygen uptake for better endurance at the source.
Recharges mitochondrial efficiency, your body’s natural energy factories.
Reduces oxidative stress, which can drain your energy quickly.
Supports Mental Clarity & Focus
OxySpark sharpens mental performance by improving cerebral circulation, allowing you to think clearly, stay focused, and maintain mental stamina, even on demanding days.
Supports neurotransmitter function, helping messages travel faster in your brain.
Combats brain fog and mental fatigue linked to poor blood flow.
Improves blood flow to the brain, enhancing mental clarity.
Customer Reviews
I thought it might be valuable to future prospective customers to know what I think about your tremendous products. I am a retired 80-year-old Doctor of Science (D.Sc.) biochemist and former national trainer for years for other nutrition products firms since the 1970's when I also was the youngest scientist speaker for the National Health Federation conventions and other organizations, and a university administrator. I am a consumer of only the finest nutritional products.
As soon as I evaluated your OxySpark formula I ordered a case of it the next day and recommend it to all my clients. No other formula in this industry has such a comprehensive formula that is remarkably effective for the generation of whole-body sustained energy generation at cellular level for increased stamina and endurance with no negative side effects or without the typical crash found in other supplements. It provides an extra energy spark to my life that is soft and smooth without being hyper.
Personally, for me I outwork and exercise people 1/3 my age every day and I also speed walk 7 miles 5 days a week. This firm's total product line is so remarkable and well researched that I would recommend them to anyone else just as I do to my own high-performance clients. Everyone comments on my brilliant memory and high energy performance as I still work full time for the joy of helping others in their senior years and being a mentor to young people as well. My own physician says I have the best chance of all their patients over the years to live to age 100 and that I didn't need to see them for any health issue.
I now prescribe OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and | have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening.
I started using OxiSpark seven yrs ago, im 2018 when I switched from L -Arginine as I saw little improvement. Ar the tine. I was the young age of 78. and I am now 85. Today, I greatly attribute the reason for my present and improved well being to OxidSpark (in addition to a healthy life style which imcldes a moderate amount of physical activity and Physical Therapy, when needed.) I started with nutritional supplementation over 50 yrs ago, at the age of 32, and it helped me greatly as I grew older. Because I genetically predisposed to have varicose veins, I also always were support stockings. Later in life, I developed other conditions including Venous Insufficuency and peripheral neuropathy (both of them aggravated by insufficient oxygen in blood circulation) In 2017, I was diagnosed eith a condition called Lipodermatosclerosis (AKA Stasis dermatitis) which looks like Lymphodema due to the swelling, but it is not the same and has a different cause). There is no recognized cure for this and it has a prognosis of becoming progressively worse.
As a result of getting this, my legs would swell up so much that I would get ulcers in my feet, and sometimes a cellulitis infection in my legs. This would happen even though I always continued to ware support stocking. This condition is not unusual for diabetics, but I do not fit in that category and my A1C is always good. But when I am dealing with an infection, such as Covid, due to inactivity, my legs would swell. So in order to avoid this, I just increase the number of times a day I take OxiSpark, and as a result it assists with my recovery.
After continuous daily use, the dark brown discoloration on my legs has disappeared and not meaning to brag, my legs look great. The many age spots on my hands and arms have gotten considerably lighter and most of them have disappeared. Not only that, the general appearance of my hands have taken on the appearance of a much younger person (without having had a special procedure to mitigate the veiny appearance comman with older women). Because it increases oxygenation, OxySpark is good for brain and heart health. Take the time and read the literature. It is true, and I am living testimony!
The only supplement that has stood the test of time.
I have used this for years and continue to feel the positive this supplement provides.
Thank You
I start every day with OxySpark for over the last four years. I am 88 years old and in very good health. No meds from my doctor.
OxySpark's Proprietary All-Natural Ingredients In A Great-Tasting Grape Flavor
OxySpark combines a proprietary blend of natural, non-GMO, gluten-free ingredients with ViNitrox™, a clinically studied compound proven to enhance nitric oxide production and vasodilation more effectively than typical arginine-based supplements.
While most nitric oxide boosters taste bitter or synthetic, OxySpark delivers a naturally sweet grape flavor you’ll actually enjoy, no choking it down, no aftertaste.
Just mix one scoop with 8 oz. of water or milk, and you’ll soon start feeling the refreshing, energizing, and circulation-boosting effects of a nitric oxide formula that’s as clean as it is effective.
Customer Reviews
I thought it might be valuable to future prospective customers to know what I think about your tremendous products. I am a retired 80-year-old Doctor of Science (D.Sc.) biochemist and former national trainer for years for other nutrition products firms since the 1970's when I also was the youngest scientist speaker for the National Health Federation conventions and other organizations, and a university administrator. I am a consumer of only the finest nutritional products.
As soon as I evaluated your OxySpark formula I ordered a case of it the next day and recommend it to all my clients. No other formula in this industry has such a comprehensive formula that is remarkably effective for the generation of whole-body sustained energy generation at cellular level for increased stamina and endurance with no negative side effects or without the typical crash found in other supplements. It provides an extra energy spark to my life that is soft and smooth without being hyper.
Personally, for me I outwork and exercise people 1/3 my age every day and I also speed walk 7 miles 5 days a week. This firm's total product line is so remarkable and well researched that I would recommend them to anyone else just as I do to my own high-performance clients. Everyone comments on my brilliant memory and high energy performance as I still work full time for the joy of helping others in their senior years and being a mentor to young people as well. My own physician says I have the best chance of all their patients over the years to live to age 100 and that I didn't need to see them for any health issue.
I now prescribe OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and | have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening.
I started using OxiSpark seven yrs ago, im 2018 when I switched from L -Arginine as I saw little improvement. Ar the tine. I was the young age of 78. and I am now 85. Today, I greatly attribute the reason for my present and improved well being to OxidSpark (in addition to a healthy life style which imcldes a moderate amount of physical activity and Physical Therapy, when needed.) I started with nutritional supplementation over 50 yrs ago, at the age of 32, and it helped me greatly as I grew older. Because I genetically predisposed to have varicose veins, I also always were support stockings. Later in life, I developed other conditions including Venous Insufficuency and peripheral neuropathy (both of them aggravated by insufficient oxygen in blood circulation) In 2017, I was diagnosed eith a condition called Lipodermatosclerosis (AKA Stasis dermatitis) which looks like Lymphodema due to the swelling, but it is not the same and has a different cause). There is no recognized cure for this and it has a prognosis of becoming progressively worse.
As a result of getting this, my legs would swell up so much that I would get ulcers in my feet, and sometimes a cellulitis infection in my legs. This would happen even though I always continued to ware support stocking. This condition is not unusual for diabetics, but I do not fit in that category and my A1C is always good. But when I am dealing with an infection, such as Covid, due to inactivity, my legs would swell. So in order to avoid this, I just increase the number of times a day I take OxiSpark, and as a result it assists with my recovery.
After continuous daily use, the dark brown discoloration on my legs has disappeared and not meaning to brag, my legs look great. The many age spots on my hands and arms have gotten considerably lighter and most of them have disappeared. Not only that, the general appearance of my hands have taken on the appearance of a much younger person (without having had a special procedure to mitigate the veiny appearance comman with older women). Because it increases oxygenation, OxySpark is good for brain and heart health. Take the time and read the literature. It is true, and I am living testimony!
The only supplement that has stood the test of time.
I have used this for years and continue to feel the positive this supplement provides.
Thank You
I start every day with OxySpark for over the last four years. I am 88 years old and in very good health. No meds from my doctor.
Clinical Studies Validate The Power Of OxySpark
OxySpark is supported by both clinical research and the real-world success stories of thousands of users.
Cell Revitalization Breakthrough
When the Bio Seare team first tested their ViNitrox™ formula, they were amazed by the results, needing three tests to confirm their findings. ViNitrox™ transforms your body into a nitric oxide-producing powerhouse by activating eNOS (endothelial nitric oxide synthase), your body's nitric oxide factory.1
In a lab study, ViNitrox™ boosted eNOS activation by 43% and increased nitric oxide production by 24%, helping cells function like they did years ago.1 This means ViNitrox™ not only enhances circulation but also restores your body's natural nitric oxide production.
Blood Flow Restoration
The researchers also discovered something even more important:
In a controlled laboratory study, they compared ViNitrox™ to leucocyanidol - a synthetic chemical specifically designed by pharmaceutical companies to dilate blood vessels.1
ViNitrox™ performed almost as well as the lab-made drug.
The blood vessels dilated by an incredible 50%.1
Here's the amazing part: ViNitrox™ works naturally without the side effects of pharmaceuticals. In comparison, L-arginine only dilates blood vessels by 1.8% to 10%, even at high doses of 7,000mg.2 This makes ViNitrox™ 5 to 25 times more effective than L-arginine.
Age-Fighting Inflammation Reduction
Here's where it gets interesting. Researchers aimed to understand why ViNitrox™ outperformed other supplements. They conducted a clinical trial with 34 individuals suffering from metabolic syndrome, each taking 500mg of ViNitrox™ daily for 28 days, the same amount that is in OxySpark and OxyBoost.
They found that ViNitrox™ reduced harmful inflammation by 50%,3 which is crucial because high inflammation damages the cells that produce nitric oxide. Unlike other blood flow supplements that can worsen inflammation, ViNitrox™ protects endothelial cells and keeps nitric oxide production steady, making it more effective over time.
Human Performance Enhancement
Dr. Louis Ignarro, Nobel Prize winner, says:
"I am convinced that nitric oxide can age-proof your cardiovascular system, keeping it much fitter than your chronological age would indicate."
ViNitrox™ enhances your body's nitric oxide production safely. In trials, users experienced:
9.7% boost in endurance 2
12.8% better effort tolerance 2
16.2% improved recovery 2
These gains were from just one dose—imagine daily use!
Customer Reviews
I thought it might be valuable to future prospective customers to know what I think about your tremendous products. I am a retired 80-year-old Doctor of Science (D.Sc.) biochemist and former national trainer for years for other nutrition products firms since the 1970's when I also was the youngest scientist speaker for the National Health Federation conventions and other organizations, and a university administrator. I am a consumer of only the finest nutritional products.
As soon as I evaluated your OxySpark formula I ordered a case of it the next day and recommend it to all my clients. No other formula in this industry has such a comprehensive formula that is remarkably effective for the generation of whole-body sustained energy generation at cellular level for increased stamina and endurance with no negative side effects or without the typical crash found in other supplements. It provides an extra energy spark to my life that is soft and smooth without being hyper.
Personally, for me I outwork and exercise people 1/3 my age every day and I also speed walk 7 miles 5 days a week. This firm's total product line is so remarkable and well researched that I would recommend them to anyone else just as I do to my own high-performance clients. Everyone comments on my brilliant memory and high energy performance as I still work full time for the joy of helping others in their senior years and being a mentor to young people as well. My own physician says I have the best chance of all their patients over the years to live to age 100 and that I didn't need to see them for any health issue.
I now prescribe OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and | have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening.
I started using OxiSpark seven yrs ago, im 2018 when I switched from L -Arginine as I saw little improvement. Ar the tine. I was the young age of 78. and I am now 85. Today, I greatly attribute the reason for my present and improved well being to OxidSpark (in addition to a healthy life style which imcldes a moderate amount of physical activity and Physical Therapy, when needed.) I started with nutritional supplementation over 50 yrs ago, at the age of 32, and it helped me greatly as I grew older. Because I genetically predisposed to have varicose veins, I also always were support stockings. Later in life, I developed other conditions including Venous Insufficuency and peripheral neuropathy (both of them aggravated by insufficient oxygen in blood circulation) In 2017, I was diagnosed eith a condition called Lipodermatosclerosis (AKA Stasis dermatitis) which looks like Lymphodema due to the swelling, but it is not the same and has a different cause). There is no recognized cure for this and it has a prognosis of becoming progressively worse.
As a result of getting this, my legs would swell up so much that I would get ulcers in my feet, and sometimes a cellulitis infection in my legs. This would happen even though I always continued to ware support stocking. This condition is not unusual for diabetics, but I do not fit in that category and my A1C is always good. But when I am dealing with an infection, such as Covid, due to inactivity, my legs would swell. So in order to avoid this, I just increase the number of times a day I take OxiSpark, and as a result it assists with my recovery.
After continuous daily use, the dark brown discoloration on my legs has disappeared and not meaning to brag, my legs look great. The many age spots on my hands and arms have gotten considerably lighter and most of them have disappeared. Not only that, the general appearance of my hands have taken on the appearance of a much younger person (without having had a special procedure to mitigate the veiny appearance comman with older women). Because it increases oxygenation, OxySpark is good for brain and heart health. Take the time and read the literature. It is true, and I am living testimony!
The only supplement that has stood the test of time.
I have used this for years and continue to feel the positive this supplement provides.
Thank You
I start every day with OxySpark for over the last four years. I am 88 years old and in very good health. No meds from my doctor.
How OxySpark Compares With Other Supplements On The Market
Generic
Supplements
Boosts nitric oxide
Clinically proven results
Doesn’t contain harmful L-Arginine
Improves blood flow
Supports cardiovascular health
Fast-acting
Boosts energy
Fights inflammation
Powerful antioxidant
Doesn’t damage Nitric Oxide-producing cells
Good Manufacturing Practice GMP Certified
Extensive 3rd Party lab tested for quality & consistency
Formulated and manufactured in The United States
What People Are Saying About OxySpark…
Customer Reviews
I thought it might be valuable to future prospective customers to know what I think about your tremendous products. I am a retired 80-year-old Doctor of Science (D.Sc.) biochemist and former national trainer for years for other nutrition products firms since the 1970's when I also was the youngest scientist speaker for the National Health Federation conventions and other organizations, and a university administrator. I am a consumer of only the finest nutritional products.
As soon as I evaluated your OxySpark formula I ordered a case of it the next day and recommend it to all my clients. No other formula in this industry has such a comprehensive formula that is remarkably effective for the generation of whole-body sustained energy generation at cellular level for increased stamina and endurance with no negative side effects or without the typical crash found in other supplements. It provides an extra energy spark to my life that is soft and smooth without being hyper.
Personally, for me I outwork and exercise people 1/3 my age every day and I also speed walk 7 miles 5 days a week. This firm's total product line is so remarkable and well researched that I would recommend them to anyone else just as I do to my own high-performance clients. Everyone comments on my brilliant memory and high energy performance as I still work full time for the joy of helping others in their senior years and being a mentor to young people as well. My own physician says I have the best chance of all their patients over the years to live to age 100 and that I didn't need to see them for any health issue.
I now prescribe OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and | have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening.
I started using OxiSpark seven yrs ago, im 2018 when I switched from L -Arginine as I saw little improvement. Ar the tine. I was the young age of 78. and I am now 85. Today, I greatly attribute the reason for my present and improved well being to OxidSpark (in addition to a healthy life style which imcldes a moderate amount of physical activity and Physical Therapy, when needed.) I started with nutritional supplementation over 50 yrs ago, at the age of 32, and it helped me greatly as I grew older. Because I genetically predisposed to have varicose veins, I also always were support stockings. Later in life, I developed other conditions including Venous Insufficuency and peripheral neuropathy (both of them aggravated by insufficient oxygen in blood circulation) In 2017, I was diagnosed eith a condition called Lipodermatosclerosis (AKA Stasis dermatitis) which looks like Lymphodema due to the swelling, but it is not the same and has a different cause). There is no recognized cure for this and it has a prognosis of becoming progressively worse.
As a result of getting this, my legs would swell up so much that I would get ulcers in my feet, and sometimes a cellulitis infection in my legs. This would happen even though I always continued to ware support stocking. This condition is not unusual for diabetics, but I do not fit in that category and my A1C is always good. But when I am dealing with an infection, such as Covid, due to inactivity, my legs would swell. So in order to avoid this, I just increase the number of times a day I take OxiSpark, and as a result it assists with my recovery.
After continuous daily use, the dark brown discoloration on my legs has disappeared and not meaning to brag, my legs look great. The many age spots on my hands and arms have gotten considerably lighter and most of them have disappeared. Not only that, the general appearance of my hands have taken on the appearance of a much younger person (without having had a special procedure to mitigate the veiny appearance comman with older women). Because it increases oxygenation, OxySpark is good for brain and heart health. Take the time and read the literature. It is true, and I am living testimony!
The only supplement that has stood the test of time.
I have used this for years and continue to feel the positive this supplement provides.
Thank You
I start every day with OxySpark for over the last four years. I am 88 years old and in very good health. No meds from my doctor.
Customer Reviews
I thought it might be valuable to future prospective customers to know what I think about your tremendous products. I am a retired 80-year-old Doctor of Science (D.Sc.) biochemist and former national trainer for years for other nutrition products firms since the 1970's when I also was the youngest scientist speaker for the National Health Federation conventions and other organizations, and a university administrator. I am a consumer of only the finest nutritional products.
As soon as I evaluated your OxySpark formula I ordered a case of it the next day and recommend it to all my clients. No other formula in this industry has such a comprehensive formula that is remarkably effective for the generation of whole-body sustained energy generation at cellular level for increased stamina and endurance with no negative side effects or without the typical crash found in other supplements. It provides an extra energy spark to my life that is soft and smooth without being hyper.
Personally, for me I outwork and exercise people 1/3 my age every day and I also speed walk 7 miles 5 days a week. This firm's total product line is so remarkable and well researched that I would recommend them to anyone else just as I do to my own high-performance clients. Everyone comments on my brilliant memory and high energy performance as I still work full time for the joy of helping others in their senior years and being a mentor to young people as well. My own physician says I have the best chance of all their patients over the years to live to age 100 and that I didn't need to see them for any health issue.
I now prescribe OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and | have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening.
I started using OxiSpark seven yrs ago, im 2018 when I switched from L -Arginine as I saw little improvement. Ar the tine. I was the young age of 78. and I am now 85. Today, I greatly attribute the reason for my present and improved well being to OxidSpark (in addition to a healthy life style which imcldes a moderate amount of physical activity and Physical Therapy, when needed.) I started with nutritional supplementation over 50 yrs ago, at the age of 32, and it helped me greatly as I grew older. Because I genetically predisposed to have varicose veins, I also always were support stockings. Later in life, I developed other conditions including Venous Insufficuency and peripheral neuropathy (both of them aggravated by insufficient oxygen in blood circulation) In 2017, I was diagnosed eith a condition called Lipodermatosclerosis (AKA Stasis dermatitis) which looks like Lymphodema due to the swelling, but it is not the same and has a different cause). There is no recognized cure for this and it has a prognosis of becoming progressively worse.
As a result of getting this, my legs would swell up so much that I would get ulcers in my feet, and sometimes a cellulitis infection in my legs. This would happen even though I always continued to ware support stocking. This condition is not unusual for diabetics, but I do not fit in that category and my A1C is always good. But when I am dealing with an infection, such as Covid, due to inactivity, my legs would swell. So in order to avoid this, I just increase the number of times a day I take OxiSpark, and as a result it assists with my recovery.
After continuous daily use, the dark brown discoloration on my legs has disappeared and not meaning to brag, my legs look great. The many age spots on my hands and arms have gotten considerably lighter and most of them have disappeared. Not only that, the general appearance of my hands have taken on the appearance of a much younger person (without having had a special procedure to mitigate the veiny appearance comman with older women). Because it increases oxygenation, OxySpark is good for brain and heart health. Take the time and read the literature. It is true, and I am living testimony!
The only supplement that has stood the test of time.
I have used this for years and continue to feel the positive this supplement provides.
Thank You
I start every day with OxySpark for over the last four years. I am 88 years old and in very good health. No meds from my doctor.
OxySpark Supplement Facts
FREQUENTLY ASKED QUESTIONS
Got questions? We’ve got answers.
How long does it take to feel the effects of OxySpark™?
Most users begin to feel noticeable improvements in circulation, energy, and focus within 7–14 days. For optimal, long-lasting results, we recommend consistent daily use for at least 30 days.
What makes OxySpark different from other nitric oxide supplements?
While most blood flow supplements rely on outdated L-Arginine formulas, OxySpark skips synthetic aminos entirely. Instead, it uses ViNitrox — a clinically studied blend of apple and grape stem cell polyphenols that’s been shown to increase circulation by 50%, boost nitric oxide by 24%, and reduce inflammation naturally.
Is OxySpark safe for people with high blood pressure?
Yes — OxySpark is designed to support healthy blood pressure by improving vascular function and promoting smoother circulation. However, if you're currently taking medication or managing a medical condition, we always recommend consulting your healthcare provider first.
Will it make me feel jittery like caffeine?
Not at all. OxySpark contains zero stimulants. It works by increasing blood flow and oxygen delivery at the cellular level, helping your body feel naturally energized without any crash or weird feeling.
When is the best time to take OxySpark™?
Mix one scoop with 8 oz of water or your favorite drink once daily. Morning or early afternoon works best to support all-day circulation and energy.
Is there a money-back guarantee?
Absolutely. If you don’t feel a difference in energy, clarity, or circulation within 90 days, simply reach out, and we’ll refund your order. No questions asked.
Who should take OxySpark™?
OxySpark is ideal for adults looking to improve circulation, energy, memory, and cardiovascular health, especially those over 50 or anyone experiencing cold extremities, fatigue, or brain fog due to poor blood flow.
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Over 29,000 Satisfied Customers
Clinically Proven Formula
90-Day Money-Back Guarantee
Free Shipping on Multi-Bottle Orders
29,000+ Happy Customers
Clinically Proven Formula
90-Day Money-Back Guarantee
Free Shipping on Multi-Bottle Orders
29,000+ Happy Customers
Clinically Proven Formula
90-Day Money-Back Guarantee
Free Shipping on Multi-Bottle Orders
29,000+ Happy Customers
Clinically Proven Formula
90-Day Money-Back Guarantee
Free Shipping on Multi-Bottle Orders
29,000+ Happy Customers
Clinically Proven Formula
90-Day Money-Back Guarantee
Customer Reviews
I thought it might be valuable to future prospective customers to know what I think about your tremendous products. I am a retired 80-year-old Doctor of Science (D.Sc.) biochemist and former national trainer for years for other nutrition products firms since the 1970's when I also was the youngest scientist speaker for the National Health Federation conventions and other organizations, and a university administrator. I am a consumer of only the finest nutritional products.
As soon as I evaluated your OxySpark formula I ordered a case of it the next day and recommend it to all my clients. No other formula in this industry has such a comprehensive formula that is remarkably effective for the generation of whole-body sustained energy generation at cellular level for increased stamina and endurance with no negative side effects or without the typical crash found in other supplements. It provides an extra energy spark to my life that is soft and smooth without being hyper.
Personally, for me I outwork and exercise people 1/3 my age every day and I also speed walk 7 miles 5 days a week. This firm's total product line is so remarkable and well researched that I would recommend them to anyone else just as I do to my own high-performance clients. Everyone comments on my brilliant memory and high energy performance as I still work full time for the joy of helping others in their senior years and being a mentor to young people as well. My own physician says I have the best chance of all their patients over the years to live to age 100 and that I didn't need to see them for any health issue.
I now prescribe OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and | have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening.
I started using OxiSpark seven yrs ago, im 2018 when I switched from L -Arginine as I saw little improvement. Ar the tine. I was the young age of 78. and I am now 85. Today, I greatly attribute the reason for my present and improved well being to OxidSpark (in addition to a healthy life style which imcldes a moderate amount of physical activity and Physical Therapy, when needed.) I started with nutritional supplementation over 50 yrs ago, at the age of 32, and it helped me greatly as I grew older. Because I genetically predisposed to have varicose veins, I also always were support stockings. Later in life, I developed other conditions including Venous Insufficuency and peripheral neuropathy (both of them aggravated by insufficient oxygen in blood circulation) In 2017, I was diagnosed eith a condition called Lipodermatosclerosis (AKA Stasis dermatitis) which looks like Lymphodema due to the swelling, but it is not the same and has a different cause). There is no recognized cure for this and it has a prognosis of becoming progressively worse.
As a result of getting this, my legs would swell up so much that I would get ulcers in my feet, and sometimes a cellulitis infection in my legs. This would happen even though I always continued to ware support stocking. This condition is not unusual for diabetics, but I do not fit in that category and my A1C is always good. But when I am dealing with an infection, such as Covid, due to inactivity, my legs would swell. So in order to avoid this, I just increase the number of times a day I take OxiSpark, and as a result it assists with my recovery.
After continuous daily use, the dark brown discoloration on my legs has disappeared and not meaning to brag, my legs look great. The many age spots on my hands and arms have gotten considerably lighter and most of them have disappeared. Not only that, the general appearance of my hands have taken on the appearance of a much younger person (without having had a special procedure to mitigate the veiny appearance comman with older women). Because it increases oxygenation, OxySpark is good for brain and heart health. Take the time and read the literature. It is true, and I am living testimony!
The only supplement that has stood the test of time.
I have used this for years and continue to feel the positive this supplement provides.
Thank You
I start every day with OxySpark for over the last four years. I am 88 years old and in very good health. No meds from my doctor.
What Are You Waiting For? Improve Your Circulation, Cognition & Energy In Just 30 Days.
If 30 days after taking OxySpark regularly, you don’t see any improvements in your energy, circulation, and overall well-being, just contact us, and we will send your money back. No questions asked.
Try OxySpark Risk-Free
Increase your energy levels naturally without stimulants.
Recommended by cardiologists for optimal cardiovascular health.
Recommended by cardiologists for optimal cardiovascular health.
Clinical Studies
OxySpark – a supplement you can actually trust. Backed by real science.
1.
Effect of ViNitrox™ on the activation of eNOs through the phosphorylation of “Serine 1177” from endothelial cells (HUVECs) as measured by flow cytometry (2010)
2.
Ex-Vivo laboratory study: ViNitrox™ stimulates the production of nitric oxide (NO) by vascular endothelium
3.
An acute dose of specific grape and apple polyphenols improves endurance performance: A randomized, crossover, double blind versus placebo controlled study
4.
Randomized, crossover, double blind, placebo controlled study of the effect a single dose of ViNitrox™ on performance upon effort and recovery in healthy volunteers
5.
Increase in fasting vascular endothelial function after short term oral l-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials
6.
Inflammation in atherosclerosis: Imaging, biomarkers and novel therapeutic opportunities
7.
Acute L-Arginine supplementation does not increase nitric oxide production in healthy subjects
8.
House, L.M., et al. Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function. Cardiovascular Diabetology. 2015.
9.
Tangadi, D., Bhutani, N., & Bhavsar, P. (2020). Coronary Artery Disease, Nitric Oxide, Insulin Resistance, Polymorphism, RFLP.
10.
Wang, Y., Cheng, K., Lam, K., Wu, D., Wang, Y., Huang, Y., Vanhoutte, P., Sweeney, G., Li, Y., & Xu, A. (2011). APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice. Diabetes, 60, 3044–3054.
11.
House, L. M., Morris, R. T., Barnes, T. M., Lantier, L., Cyphert, T. J., McGuinness, O., & Otero, Y. (2015). Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance. Cardiovascular Diabetology
12.
Sprague AH, Khalil RA. "Inflammatory cytokines in vascular dysfunction." Biochem Pharmacol. 2009
13.
Steyers CM, Miller FJ. "Endothelial dysfunction in chronic inflammatory diseases." Int J Mol Sci. 2014
14.
Gimbrone MA, García-Cardeña G. "Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis." Circ Res. 2016
15.
Torregrossa, A.C., Aranke, M., & Bryan, N.S. (2011). "Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly." Journal of Geriatric Cardiology, 8(4), 230-242.
16.
Taddei, S., et al. (2000). "Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes." Circulation, 101, 2896-2901.
17.
Scalera, F., Closs, E. I., Flick, E., Martens-Lobenhoffer, J., Boissel, J. P., Lendeckel, U., Heimburg, A., & Bode-Böger, S. M. (2009). Paradoxical effect of L-arginine: Acceleration of endothelial cell senescence. Biochemical and Biophysical Research Communications, 386(4), 650–655.
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† Disclaimer: These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. Use only as directed. Consult your healthcare provider before using supplements or providing supplements to children under the age of 18. The information provided herein is intended for your general knowledge only and is not intended to be, nor is it, medical advice or a substitute for medical advice. If you have or suspect you have, a specific medical condition or disease, please consult your healthcare provider.